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FLEXISEQ Gel 50g

€17.50

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FLEXISEQ Gel 50g View Large Image
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FLEXISEQ is a pain relieving gel that has been specifically designed to combat joint pain associated with osteoartritis. FLEXISEQ is formulated to combat joint pain using a new method. FLEXISEQ is drug free and is topically applied to the joint in pain.

Daily application in the morning and evening can bring improvement in mobility and reduce pain in as little as two days, although most people begin to notice the benefits within just a week.

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FLEXISEQ is clinically proven to greatly reduce pain and restore joint function (mobility). FLEXISEQ was shown to be as effective as a leading oral prescription-only medicine in trials with hundreds of patients.


FLEXISEQ ingredients are drug-free. This meansFLEXISEQ won't interact with medication you may be taking for your pain or any other ailment. FLEXISEQ benefits from an excellent safety profile avoiding the documented risks that may be associated with many common pain medicines. We do recommend that all new users carrying out a patch test of the product before commiting to regular usage.

How to use FLEXISEQ

Apply twice daily to the affected joint. It is recommended that you apply FLEXISEQ in the morning and at night to skin that is clean and dry.

Use enough gel to evenly cover the whole joint. For example, when treating the knee, we recommend using a gel length of around 7cm (roughly half the length of the FLEXISEQ 50g tube). On this basis, a single tube of Flexseq will last around 10-14 days.

It is important to allow FLEXISEQ to dry before covering, you do not need to keep rubbing the gel in. Failure to do so may impair the absorption of the product. The gel should dry after no more than 10 minutes. If drying time takes longer, just use a little less next time.

What is FLEXISEQ?
FLEXISEQ is a topically applied drug-free gel which is clinically proven to safely relieve the pain and improve the joint stiffness associated with osteoarthritis (OA). There is extensive clinical data available from several randomised, double-blind clinical trials and FLEXISEQ is approved as a medical device for the treatment of all joints affected by OA.

How well does FLEXISEQ work?
There have been 5 clinical studies evaluating the safety and efficacy of FLEXISEQ, and these consistently demonstrated reductions in pain of around 50% and improvements in physical function of around 40% 1,2,3.

One of the key studies in this extensive clinical programme also demonstrated that FLEXISEQ is as effective at alleviating joint pain as a leading oral prescription drug which, unlike FLEXISEQ, but in common with other treatments in this same class of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), has well recognised systemic side effects (problems resulting from the drug being spread throughout the body). In this comparison study, patients treated with FLEXISEQ reported a reduction in joint pain and stiffness that was equivalent to that reported by the patients taking oral celecoxib2.

These same studies have also demonstrated the safety of FLEXISEQ: the most commonly reported side effects were mild/moderate skin irritations. In addition, there have now been over 6 million applications of the product in early markets and, unlike other oral and topical treatments, there have been no reported incidences of systemic side effects (such as heart attacks, strokes and gastro-intestinal problems linked to NSAIDs) related to the use of FLEXISEQ. This lack of systemic exposure also makes FLEXISEQ safe to use alongside any other therapy.

How safe is FLEXISEQ?
FLEXISEQ is a drug-free, topical treatment with excellent safety and tolerability. The extensive clinical programme and market experience demonstrates this safety. There have been over 6 million applications of the product in early markets and, unlike other routinely used oral and topical treatments, there have been no reported incidences of systemic side effects (such as heart attacks, strokes and gastro-intestinal problems linked to NSAIDs) related to the use of FLEXISEQ. The absence of drug also makes FLEXISEQ™ safe to use alongside any other therapy.

The majority of Adverse Events (AEs) reported have been skin and subcutaneous tissue complaints, mild to moderate in intensity and will resolve over time without stopping treatment 1,2,3.

I have experienced a reaction to FLEXISEQ; should I stop treatment?
FLEXISEQ has an excellent safety and tolerability profile. Unlike many pain killers taken by patients, the majority of the side effects seen in clinical trials were mild-to-moderate skin irritations. Most patients in the clinical trials continued using the product, even if skin reactions were experienced. The majority of these irritations will resolve over time without stopping treatment. In the case of continuing side effects, you may first reduce the dose (e.g. from twice daily to once daily) and only if this does not improve the condition should you consider interrupting or stopping treatment.

In you are at all worried, please consult a doctor or a pharmacist.

How should I apply the gel?
FLEXISEQ should be applied twice daily to the affected joint, usually in the morning and the evening. Use enough gel to evenly cover the soft tissue around the joint.

For the knee: a twice daily dose of 2.2 g corresponding to approximately 7 cm line of gel as squeezed from the tube is recommended. The gel should not be applied to the patella (knee cap) and should include the area at the back of the knee. FLEXISEQ must be allowed to dry before covering; drying should take no longer than 10 minutes if the product is applied to clean, dry skin. If drying takes longer than this, ensure that the skin is dry (for example if applying after a bath or shower) and try using a little less gel. Alternatively a hair dryer [on a low / cool setting] can be used to speed up the drying time. If the drying time is considerably less than 10 minutes then a little more gel can be used next time. Please wash your hands after applying the gel.

For the hip: Locate the edge of your pelvis (or hipbone) at your side and apply the gel approximately two inches below where you can no longer feel bone but soft tissue. Do not spread towards the buttocks but instead towards your centre line. It is difficult to give precise dosing amounts for the hip as the size of this joint can vary widely from patient to patient. If you consider yourself to be of average weight, use approximately 3 g (approximately 10 cm line of gel as squeezed from the tube) to cover an area of approximately the size of your hand. If you believe you are above average size, you may need to apply a little more. You will know if you have applied the correct amount as it should take around 10 minutes to dry. For the first few applications the amount applied may need to be increased or decreased to achieve a 10 minute drying time. Alternatively a hair dryer [on a low / cool setting] may be used gently to dry the area. In order to achieve optimum effect, FLEXISEQ gel should be applied twice daily to the whole affected joint, not rubbed in but left to dry. The joint should not be covered until the gel has completely dried. Please wash your hands after applying the gel.

For the shoulder: It is difficult to give precise dosing amounts for the shoulder as the size of this joint and location of the pain varies from patient to patient. If you consider yourself to be of average weight, use approximately 2.2 g corresponding to approximately 7 cm line of gel as squeezed from the tube to cover the area corresponding to the location of your pain. If you believe you are above average size, you may need to apply a little more. You will know if you have applied the correct amount as it should take around 10 minutes to dry (although may remain tacky after this time). Alternatively a hair dryer [on a low / cool setting] may be used gently to dry the area. For the first few applications the amount applied may need to be increased or decreased to achieve a 10 minute drying time. In order to achieve optimum effect, FLEXISEQ gel should be applied twice daily to the whole affected joint, not rubbed in but left to dry. The joint should not be covered until the gel has completely dried. Please wash your hands after applying the gel.


What should I do if the product is applied incorrectly?
FLEXISEQ has an excellent tolerability and safety profile.

a. If too much gel has been applied – there are no safety issues with applying too much gel. It will simply take longer for all of the gel to dry off. You can wipe off excess gel and apply less the next time. As a general guidance it should not take longer than 10 minutes for the gel to dry off completely.
b. If gel has entered the eyes – as with most topical treatments, you should avoid allowing the gel to enter the eyes. If gel does enter the eyes, they should be rinsed with plenty of cold water. If excessive stinging/symptoms occur, please consult a pharmacist or doctor.
c. If gel has been eaten –the gel should not be taken orally, but if it has been ingested, it should not cause major problems. As with other medical products, care should be taken to store it out of reach of children. If symptoms occur, please consult a pharmacist or doctor.
As with all treatments, if you have any concerns, please consult a doctor or pharmacist.


How does FLEXISEQ work?
FLEXISEQ is a drug-free gel that relieves pain and stiffness associated with osteoarthritis. FLEXISEQ exerts its pain-relieving effect via lubrication of the joint which is a physical mode of action. It has no pharmacological, metabolic or immunological activity.
FLEXISEQ is a gel containing Sequessome vesicles, which are tiny phospholipid spheres. As the gel dries on the skin, these spheres change their shape and pass through the skin, then on into the joint where they lubricate the surface of the cartilage to provide relief from pain and stiffness.
Phospholipids are naturally occurring substances in the body and are known to have numerous functions, including lubrication of articulating cartilage8. Patients with joint disorders such as OA have been found to have reduced levels of phospholipids in their synovial fluid9 and this is one of the factors contributing to the pain and loss of joint function in patients with OA8. There is also strong evidence in published literature that liposomes (phospholipids) act as a bio-lubricant in the knee joint, and hence can reduce pain and improve mobility8.
Research has shown that following topical application of FLEXISEQ, the Sequessome™ vesicles pass through the skin and penetrate the synovial fluid within the joint where they collect on cartilage surfaces10. The physical properties of the Sequessome™ vesicles make them particularly efficient at lubricating.

How long does the pain relief last once treatment is stopped?
As above. FLEXISEQ works by delivery of lubricating vesicles into the joint. These vesicles are made of naturally occurring phospholipids and will be broken down over time and will need replacing. Therefore patients will need to continue to use FLEXISEQ™ in order to maintain efficacy.

Am I suitable for FLEXISEQ?
Any patients with pain associated with OA can use FLEXISEQ. It is particular interest to:

Patients for whom other treatment options (NSAIDs, COX-II inhibitors and paracetamol) should be avoided or used as little as possible, either because of their other medical conditions, their age or their concomitant medications. This includes patients with cardio-vascular or gastro-intestinal risk factors and problems.
Patients who are not receiving adequate symptomatic relief from their current treatment and want to add another option.
Cautions: Patients with known sensitivity to any of the ingredients listed on the box should not use FLEXISEQ. Pregnant women should consult their doctor (see Q32).

Can FLEXISEQ be used alongside medications?
FLEXISEQ does not contain any active pharmaceutical ingredients and therefore cannot compromise any existing oral medications, such as low-dose aspirin, paracetamol, diuretics. If you have any specific concerns, a pharmacist or doctor should be consulted.

How should I store FLEXISEQ?
FLEXISEQ is easy to look after, and can be stored at room temperature (between 8°C and 25°C). It does not need to be refrigerated and should not be stored in the fridge. After first opening the tube, the product should be used within 3 months.

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